How does it spread?
Clostridium Perfringens Toxins
Incubation is 1 - 6 hours which produces respiratory distress
syndrome and respiratory failure. Absorbed toxin can lead to intravascular
hemolysis, thrombocytopenia, and liver damage.
Early symptoms beginning within minutes of exposure include burning skin pain, redness, tenderness, blistering, and progression to skin death with leathery blackening and sloughing of large areas of skin.
Upper respiratory exposure may result in nasal itching, pain, sneezing, epistaxis, and runny nose.
Pulmonary/tracheobronchial toxicity produces difficulty in breathing, wheezing, and coughing. Mouth and throat exposure causes pain and blood tinged saliva and sputum.
Loss of appetite, nausea, vomiting and watery or bloody diarrhea with crampy abdominal pain occurs with gastrointestinal toxicity.
Eye pain, tearing, redness, foreign body sensation and blurred vision may follow ocular exposure.
Skin symptoms occur in minutes to hours and eye symptoms in minutes.
Systemic toxicity can occur via any route of exposure, and results in weakness, prostration, dizziness, ataxia, and loss of coordination. Irregular heartbeat, hypothermia, and hypotension follow in fatal cases. The most common symptoms are vomiting, diarrhea, skin involvement with burning pain, redness and pruritus, rash or blisters, bleeding, and difficulty in breathing. A late effect of systemic absorption is pancytopenia, predisposing to bleeding and sepsis.
Gas gangrene results from wound contamination with soil containing
spores of C. perfringens. Clostridial food poisoning follows eating foods contaminated
with soil or feces and then stored under conditions that allow
the organism to reproduce.
This toxin is not communicable person to person.
Should be suspected if an aerosol attack occurs in the form of
"yellow rain" with droplets of variously pigmented oily fluids
contaminating clothes and the environment. Confirmation requires
testing of blood, tissue and environmental samples.
There are no specific antitoxins or antidotes available. Medical
management consists of supportive care. Patients may require a
tracheotomy or other means of assisted breathing.
None available. There is no pre-exposure or post-exposure prevention.
Prognosis is poor. Death may occur in minutes, hours or days.
USAMRIID's Medical Management of Biological Casualties Handbood; Fourth Edition February 2001; pages 9-10; http://usamriid.detrick.army.mil/education/bluebook/bluebook.pdf
Federation of American Scientists; http://www.fas.org/nuke/intro/bw/agent.htm
Virtual Naval Hospital: Treatment of Biological Warfare Agent Casualties; http://www.vnh.org/FM8284/index.html
All contents © 2001 Stan and Holly Deyo. All rights reserved.
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How does it spread?